Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26260166 | 1.00 | USP7 (0.45) | USP7RXRARXRBRXRGMAPK1 | |
| SCHEMBL30452288 | 0.84 | VEGFA (0.47) | USP7MAPK1MAPK10RAB9ASMN1; SMN2 | |
| SCHEMBL24257856 | 0.82 | USP7 (0.43) | USP7MAPK1MAPK10RAB9ASMN1; SMN2 | |
| SCHEMBL30454075 | 0.79 | PTGER1 (0.47) | RXRARXRBRXRGMAPK1MAPK10 | |
| SCHEMBL24257585 | 0.79 | PTGER1 (0.47) | RXRARXRBRXRGMAPK1MAPK10 | |
| SCHEMBL30453121 | 0.74 | MAOB (0.47) | MAPK1RAB9ASMN1; SMN2NPC1MRGPRX4 | |
| SCHEMBL24257685 | 0.74 | MAOB (0.47) | MAPK1RAB9ASMN1; SMN2NPC1MRGPRX4 | |
| SCHEMBL31636637 | 0.74 | PTGER1 (0.48) | RXRARXRBRXRGMAPK1MAPK10 | |
| SCHEMBL24257604 | 0.73 | PTGER1 (0.44) | RXRARXRBRXRGMAPK1MAPK10 | |
| SCHEMBL30546880 | 0.73 | PTGER1 (0.44) | RXRARXRBRXRGMAPK1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |