Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257512 | 1.00 | MRGPRX4 (0.46) | MRGPRX4SYKDHODHPPARDRXRA | |
| SCHEMBL30546847 | 0.89 | SYK (0.42) | MRGPRX4SYKDHODHPPARDPDE10A | |
| SCHEMBL24257759 | 0.85 | KDM4E (0.42) | DHODHPTPN1MAP4K4PTGER1 | |
| SCHEMBL30546849 | 0.85 | KMT2A (0.41) | MRGPRX4 | |
| SCHEMBL24257580 | 0.85 | KMT2A (0.41) | MRGPRX4 | |
| SCHEMBL24257740 | 0.82 | PDE10A (0.39) | MRGPRX4SYKPPARDPDE10A | |
| SCHEMBL30452657 | 0.82 | PDE10A (0.39) | MRGPRX4SYKPPARDPDE10A | |
| SCHEMBL24257669 | 0.81 | C5AR1 (0.43) | MRGPRX4DHODHPPARDPTGER1 | |
| SCHEMBL30453291 | 0.81 | C5AR1 (0.43) | MRGPRX4DHODHPPARDPTGER1 | |
| SCHEMBL24257621 | 0.80 | MCL1 (0.44) | MRGPRX4DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |