Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.60 |
| ▸ | MTOR | P42345 | 14/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 12/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25722311 | 1.00 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL27272628 | 0.80 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL25719399 | 0.80 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL25724481 | 0.80 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL16094600 | 0.80 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL25277910 | 0.79 | PIK3CD (0.61) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL258487 | 0.76 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL31705145 | 0.75 | PTK2 (0.63) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL25719397 | 0.75 | PTK2 (0.63) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL13610136 | 0.72 | CHEK1 (0.68) | PIK3CAMTORPIK3CGMAPK1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444289-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107592-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |