Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.69 |
| ▸ | SCN4A | P35499 | 2/20 | 0.59 |
| ▸ | CD74 | P04233 | 1/20 | 0.56 |
| ▸ | MIF | P14174 | 1/20 | 0.56 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 3/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25272432 | 1.00 | NOTUM (0.69) | NOTUMSCN4ACD74MIFCYP2E1 | |
| SCHEMBL17279815 | 0.86 | NOTUM (0.74) | NOTUMSCN4ACD74MIFCYP2E1 | |
| SCHEMBL27876939 | 0.78 | SCN4A (0.73) | NOTUMSCN4ACD74MIFCYP2E1 | |
| SCHEMBL980356 | 0.77 | NOTUM (0.62) | NOTUMSCN4ACD74MIFCYP2E1 | |
| SCHEMBL21415566 | 0.77 | NOTUM (0.62) | NOTUMSCN4ACD74MIFCYP2E1 | |
| SCHEMBL1786909 | 0.77 | NOTUM (0.62) | NOTUMSCN4ACD74MIFCYP2E1 | |
| SCHEMBL6054146 | 0.77 | NOTUM (0.62) | NOTUMSCN4ACD74MIFCYP2E1 | |
| SCHEMBL797168 | 0.77 | NOTUM (0.57) | NOTUMSCN4ACD74MIFCYP2E1 | |
| SCHEMBL23105893 | 0.76 | PDPK1 (0.68) | NOTUMSCN4ACD74MIFCYP2E1 | |
| SCHEMBL104517 | 0.75 | SCN4A (0.79) | NOTUMSCN4ACYP2E1CYP2A6CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444289-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107592-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |