Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.51 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.42 |
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.39 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30459023 | 0.90 | CRBN (0.51) | CRBNIKZF3IKZF2MAOAMAOB | |
| SCHEMBL30459790 | 0.88 | CRBN (0.53) | CRBNIKZF3IKZF2DDB1IKZF1 | |
| SCHEMBL25278381 | 0.83 | IKZF2 (0.59) | CRBNIKZF3IKZF2DDB1IKZF1 | |
| SCHEMBL30458583 | 0.83 | CRBN (0.53) | CRBNIKZF3IKZF2DDB1IKZF1 | |
| SCHEMBL30459010 | 0.83 | CRBN (0.52) | CRBNIKZF3IKZF2DDB1IKZF1 | |
| SCHEMBL30460131 | 0.82 | CRBN (0.51) | CRBNIKZF3IKZF2DDB1IKZF1 | |
| SCHEMBL30459878 | 0.81 | CRBN (0.53) | CRBNIKZF3IKZF2DDB1IKZF1 | |
| SCHEMBL30458608 | 0.80 | CRBN (0.49) | CRBNIKZF3IKZF2DDB1 | |
| SCHEMBL30458350 | 0.80 | CRBN (0.51) | CRBNIKZF3IKZF2DDB1IKZF1 | |
| SCHEMBL25647259 | 0.80 | CRBN (0.56) | CRBNIKZF3DDB1GSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | claimed |