Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.55 |
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.50 |
| ▸ | IKZF1 | Q13422 | 3/20 | 0.50 |
| ▸ | WIZ | O95785 | 3/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25646993 | 1.00 | CRBN (0.55) | CRBNIKZF2IKZF1WIZCSNK1A1 | |
| SCHEMBL30460171 | 1.00 | CRBN (0.55) | CRBNIKZF2IKZF1WIZCSNK1A1 | |
| SCHEMBL25646994 | 0.93 | CRBN (0.55) | CRBNIKZF2IKZF1WIZCSNK1A1 | |
| SCHEMBL30458594 | 0.91 | CRBN (0.53) | CRBNIKZF2IKZF1WIZGSPT1 | |
| SCHEMBL30458865 | 0.91 | CRBN (0.53) | CRBNIKZF2IKZF1WIZGSPT1 | |
| SCHEMBL30459906 | 0.84 | CRBN (0.53) | CRBNDDB1IKZF3 | |
| SCHEMBL25647153 | 0.84 | CRBN (0.54) | CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL31077241 | 0.83 | CRBN (0.59) | CRBNIKZF2IKZF1CSNK1A1GSPT1 | |
| SCHEMBL25646990 | 0.83 | CRBN (0.59) | CRBNIKZF2IKZF1CSNK1A1GSPT1 | |
| SCHEMBL30493382 | 0.83 | CRBN (0.59) | CRBNIKZF2IKZF1CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |