Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683125 | 1.00 | EGFR (0.48) | EGFRMKNK1MKNK2 | |
| SCHEMBL17683127 | 0.87 | EGFR (0.47) | EGFRMKNK1MKNK2 | |
| SCHEMBL30459810 | 0.87 | EGFR (0.47) | EGFRMKNK1MKNK2 | |
| SCHEMBL29464136 | 0.85 | EGFR (0.48) | EGFR | |
| SCHEMBL17683128 | 0.85 | LCK (0.40) | EGFRMKNK1MKNK2 | |
| SCHEMBL30459789 | 0.85 | LCK (0.40) | EGFRMKNK1MKNK2 | |
| SCHEMBL17683143 | 0.85 | EGFR (0.53) | EGFR | |
| SCHEMBL19100929 | 0.83 | EGFR (0.54) | EGFR | |
| SCHEMBL19254875 | 0.83 | EGFR (0.47) | EGFRMKNK1MKNK2 | |
| SCHEMBL17682978 | 0.82 | EGFR (0.69) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |