Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.47 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.47 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683240 | 1.00 | HTT (0.55) | HTTDYRK1ACREBBPBRPF1BRD9 | |
| SCHEMBL28553930 | 0.83 | DYRK1A (0.48) | HTTDYRK1ACREBBPNPSR1MEN1 | |
| SCHEMBL19103337 | 0.81 | GSK3B (0.43) | DYRK1AFLT3EGFR | |
| SCHEMBL29419125 | 0.80 | MKNK1 (0.50) | HTTDYRK1AFLT3EGFRALDH1A1 | |
| SCHEMBL5096322 | 0.80 | MKNK1 (0.50) | HTTDYRK1AFLT3EGFRALDH1A1 | |
| SCHEMBL19337232 | 0.77 | CCNB2 (0.44) | DYRK1ACCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL17384845 | 0.76 | GAA (0.52) | MEN1KMT2AEGFRPOLBALDH1A1 | |
| SCHEMBL17542623 | 0.76 | MKNK1 (0.53) | DYRK1AMEN1KMT2APOLBKDM4E | |
| SCHEMBL17542604 | 0.76 | MKNK2 (0.53) | DYRK1APOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19699869 | 0.75 | EGFR (0.51) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |