Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.68 |
| ▸ | CDK2 | P24941 | 11/20 | 0.67 |
| ▸ | CDC7 | O00311 | 10/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.49 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5659028 | 1.00 | RPS6KA5 (0.68) | RPS6KA5CDK2CDC7ROCK1MKNK1 | |
| SCHEMBL19100953 | 0.82 | CDC7 (0.68) | RPS6KA5CDK2CDC7MAPT | |
| SCHEMBL19337066 | 0.81 | RPS6KA5 (0.61) | RPS6KA5CDK2CDC7ROCK1MAP3K14 | |
| SCHEMBL19100965 | 0.81 | RPS6KA5 (1.00) | RPS6KA5CDK2CDC7ROCK1MAP3K14 | |
| SCHEMBL19100396 | 0.81 | CDC7 (0.68) | RPS6KA5CDK2CDC7ROCK1MKNK2 | |
| SCHEMBL9377410 | 0.80 | CDC7 (1.00) | CDK2CDC7ROCK1MAP3K14 | |
| SCHEMBL19533417 | 0.80 | CDK2 (0.67) | RPS6KA5CDK2CDC7ROCK1MKNK1 | |
| SCHEMBL30753972 | 0.80 | CDC7 (1.00) | CDK2CDC7ROCK1MAP3K14 | |
| SCHEMBL17888130 | 0.79 | CDC7 (0.68) | RPS6KA5CDK2CDC7ROCK1MAP3K14 | |
| SCHEMBL28664988 | 0.79 | CDC7 (0.56) | RPS6KA5CDK2CDC7ROCK1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113563332-B | Novel pyrimidines as EGFR inhibitors and methods of treating disorders | 达纳－法伯癌症研究所公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |