Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5006172 | 1.00 | KDM4E (0.45) | KDM4EGAACA12CA1CA2 | |
| SCHEMBL15975836 | 0.85 | HPGD (0.51) | KDM4EGAACA12CA1CA2 | |
| SCHEMBL26699213 | 0.84 | KDM4E (0.44) | KDM4EGAACA12CA1CA2 | |
| SCHEMBL17176838 | 0.83 | KDM4E (0.45) | KDM4EGAACA12CA1CA2 | |
| SCHEMBL30753250 | 0.82 | KDM4E (0.47) | KDM4EGAACA12CA1CA2 | |
| SCHEMBL8833705 | 0.82 | HIF1A (0.48) | KDM4EGAAHTTHIF1AHPGD | |
| SCHEMBL22276656 | 0.82 | HIF1A (0.45) | KDM4EGAACA12CA1CA2 | |
| SCHEMBL27275389 | 0.82 | KDM4E (0.47) | KDM4EGAACA12CA1CA2 | |
| SCHEMBL27358606 | 0.82 | KDM4E (0.47) | KDM4EGAACA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL12500081 | 0.81 | KDM4E (0.46) | KDM4EGAACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118660872-A | Pyrimidine compound, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-116496252-A | Pyrimidine compound, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2023-07-28 | — | — | CN | disclosed |