Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | IP6K1 | Q92551 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.34 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.34 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | MGMT | P16455 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27616663 | 0.86 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C19IP6K1 | |
| SCHEMBL29404312 | 0.84 | CYP3A4 (0.67) | CYP1A2CYP3A4CYP2D6CYP2C19IP6K1 | |
| SCHEMBL101669 | 0.84 | CYP3A4 (0.67) | CYP1A2CYP3A4CYP2D6CYP2C19IP6K1 | |
| SCHEMBL16341910 | 0.81 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C19XDH | |
| SCHEMBL1271566 | 0.78 | CYP1A2 (0.40) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL28996831 | 0.74 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2D6CYP2C19MAPT | |
| SCHEMBL29249244 | 0.70 | CYP3A4 (0.45) | CYP1A2CYP3A4CYP2D6CYP2C19IP6K1 | |
| SCHEMBL3907002 | 0.69 | CDK1 (0.48) | CYP1A2CYP3A4CYP2D6CYP2C19IP6K1 | |
| SCHEMBL30150726 | 0.69 | CYP3A4 (0.44) | CYP1A2CYP3A4CYP2D6CYP2C19IP6K1 | |
| SCHEMBL28117129 | 0.69 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2D6CYP2C19CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115715797-A | Compositions and methods for treating and preventing macular degeneration | 建新公司 | 2023-02-28 | — | — | CN | disclosed |
| US-7709220-B2 | monitoring the efficacy of a BAFF-R (a B-cell activating factor belonging to the Tumor Necrosis Factor family) antagonist in the treatment of a disease or disorder associated with aberrant levels of B-cells or B-cell activity | BIOGEN IDEC MA INC. (US) | 2010-05-04 | — | — | US | disclosed |
| US-7638327-B2 | polypeptides related to a receptor to BAFF (a B-cell activating factor belonging to the Tumor Necrosis Factor family, which is associated with expression of B-cells and immunoglobulins); treatment of cancers, lymphomas, autoimmune diseases related to B-cells | BIOGEN IDEC MA INC. (US) | 2009-12-29 | — | — | US | disclosed |
| US-20080050372-A1 | INHIBITION OF ALPHA-2 HS GLYCOPROTEIN (AHSG/FETUIN) IN OBESITY AND INSULIN CONTROL OF GLUCOSE HOMEOSTASIS | WAYNE STATE UNIVERSITY (US) | 2008-02-28 | — | — | US | disclosed |
| US-20060240517-A1 | polypeptides related to a receptor to BAFF (a B-cell activating factor belonging to the Tumor Necrosis Factor family, which is associated with expression of B-cells and immunoglobulins); treatment of cancers, lymphomas, autoimmune diseases related to B-cells | BIOGEN MA INC. | 2006-10-26 | — | — | US | disclosed |
| US-20060240520-A1 | monitoring the efficacy of a BAFF-R (a B-cell activating factor belonging to the Tumor Necrosis Factor family) antagonist in the treatment of a disease or disorder associated with aberrant levels of B-cells or B-cell activity | BIOGEN MA INC. | 2006-10-26 | — | — | US | disclosed |
| US-20030110519-A1 | Cognition activators, sleep disorders, eating disorders, psychological disorders | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-06-12 | — | — | US | disclosed |
| US-20020168708-A1 | Nucleotide sequences coding polypeptide for use in the treatment of parkinson's, chronic obstructive airways, irritable bowel syndrome, muscle and urogenital disorders | MILLENNIUM PHARMACEUTICALS, INC. | 2002-11-14 | — | — | US | disclosed |