Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25230210 | 1.00 | USP30 (0.35) | USP30NR1H2BACE1BACE2AURKA | |
| SCHEMBL25279258 | 0.86 | NR1H2 (0.40) | USP30NR1H2AAK1NR1H3 | |
| SCHEMBL30466370 | 0.83 | NR1H2 (0.48) | NR1H2NR1H3 | |
| SCHEMBL616604 | 0.83 | NR1H2 (0.48) | NR1H2NR1H3 | |
| SCHEMBL15011465 | 0.82 | NR1H2 (0.41) | USP30NR1H2BACE1BACE2NR1H3 | |
| SCHEMBL25787198 | 0.82 | USP30 (0.36) | USP30NR1H2AURKACDK2AAK1 | |
| SCHEMBL3424231 | 0.82 | USP30 (0.39) | USP30NR1H2NR1H3 | |
| SCHEMBL31275642 | 0.82 | MEN1 (0.32) | USP30AAK1 | |
| SCHEMBL14854558 | 0.80 | ABCB1 (0.39) | NR1H2NR1H3 | |
| SCHEMBL24755242 | 0.80 | NR1H2 (0.44) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448105-A1 | HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF DISEASE | VIR Biotechnology, Inc. (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114428-A1 | HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF DISEASE | Vir Biotechnology, Inc. (US) | 2023-06-22 | — | — | WO | disclosed |