Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162800 | 0.79 | TSHR (0.53) | TSHRRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL9664550 | 0.78 | TSHR (0.56) | TSHRRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL261326 | 0.78 | — | — | |
| SCHEMBL14436880 | 0.77 | TSHR (0.84) | TSHRRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL13041458 | 0.76 | TSHR (0.53) | TSHRRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5160589 | 0.76 | TSHR (0.53) | TSHRRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL6536779 | 0.75 | — | — | |
| SCHEMBL18205594 | 0.75 | — | — | |
| SCHEMBL3170534 | 0.74 | TSHR (0.67) | TSHRRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5158635 | 0.74 | TSHR (0.56) | TSHRRAB9ASMN1; SMN2NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111511730-B | Amide substituted indole compounds useful as TLR inhibitors | 百时美施贵宝公司 | 2023-07-25 | — | — | CN | disclosed |