Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 17/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 17/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 13/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.44 |
| ▸ | USP2 | O75604 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 8/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.38 |
| ▸ | TSHR | P16473 | 11/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 13/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30467757 | 0.94 | CYP1A2 (0.47) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL24252884 | 0.94 | CYP1A2 (0.47) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL30467737 | 0.86 | CYP1A2 (0.43) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL24252840 | 0.86 | CYP1A2 (0.43) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| Acetic Acid SCHEMBL30467760 | 0.84 | CYP1A2 (0.43) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| Acetic Acid SCHEMBL30467707 | 0.81 | CYP1A2 (0.50) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL24252770 | 0.80 | CYP1A2 (0.52) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL30451382 | 0.80 | CYP1A2 (0.52) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL24252310 | 0.78 | CYP1A2 (0.43) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL30467671 | 0.78 | CYP1A2 (0.43) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4185592-A1 | INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF | Annexon, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |