Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 16/20 | 0.55 |
| ▸ | FLT3 | P36888 | 16/20 | 0.55 |
| ▸ | KIT | P10721 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051888 | 1.00 | CHEK1 (0.55) | CHEK1FLT3KITMAPTIGF1R | |
| SCHEMBL23754874 | 0.96 | CHEK1 (0.57) | CHEK1FLT3KITMAPTJAK2 | |
| SCHEMBL30088400 | 0.96 | CHEK1 (0.57) | CHEK1FLT3KITMAPTJAK2 | |
| SCHEMBL30468449 | 0.93 | CHEK1 (0.52) | CHEK1FLT3KITMAPTMAP3K7 | |
| SCHEMBL23764769 | 0.93 | CHEK1 (0.52) | CHEK1FLT3KITMAPTMAP3K7 | |
| SCHEMBL4283268 | 0.87 | MAPT (0.50) | CHEK1FLT3KITMAPTIGF1R | |
| SCHEMBL25234686 | 0.86 | TYRO3 (0.59) | CHEK1FLT3KIT | |
| SCHEMBL30412224 | 0.86 | TYRO3 (0.59) | CHEK1FLT3KIT | |
| SCHEMBL23764827 | 0.86 | CHEK1 (0.75) | CHEK1FLT3KITMAP3K7RPS6KB1 | |
| SCHEMBL30741470 | 0.86 | CHEK1 (0.75) | CHEK1FLT3KITMAP3K7RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |