Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 10/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304726 | 1.00 | KDM4E (0.51) | KDM4EDRD4EPHA2ERBB2EPHB4 | |
| SCHEMBL1700868 | 0.82 | EPHA2 (0.47) | DRD4EPHA2ERBB2EPHB4ALDH1A1 | |
| SCHEMBL29262728 | 0.82 | EPHA2 (0.47) | DRD4EPHA2ERBB2EPHB4ALDH1A1 | |
| SCHEMBL305630 | 0.81 | KDM4E (0.49) | KDM4EDRD4NPC1ALDH1A1RAB9A | |
| SCHEMBL4301620 | 0.80 | EPHA2 (0.54) | DRD4EPHA2ERBB2EPHB4DRD2 | |
| SCHEMBL4301622 | 0.80 | EPHA2 (0.54) | DRD4EPHA2ERBB2EPHB4DRD2 | |
| SCHEMBL305629 | 0.77 | KDM4E (0.46) | KDM4ENPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL19423770 | 0.75 | KDM4E (0.55) | KDM4ENPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL19172469 | 0.74 | EPHA2 (0.44) | EPHA2ERBB2EPHB4NPC1ALDH1A1 | |
| SCHEMBL2795186 | 0.74 | EPHA2 (0.51) | DRD4EPHA2ERBB2EPHB4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093244-B2 | Heteroaryl urea derivatives useful for inhibiting CHK1 | ICOS CORPORATION (US) | 2012-01-10 | — | — | US | disclosed |
| EP-2330105-A1 | Heteroaryl urea derivatives useful for inhibiting CHK1 | ICOS Corporation (US) | 2011-06-08 | — | — | EP | disclosed |
| EP-1869020-B1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS CORP (US) | 2010-12-01 | — | — | EP | disclosed |
| US-20090143357-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143357-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | CHEK1, CHEK2, PCNA | KDM4E 2751/4885DRD4 4361/4885EPHA2 4060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.