Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30474145 | 0.91 | ESR2 (0.45) | MKNK1ESR2CYP3A4CYP3A5NR1H2 | |
| SCHEMBL30474119 | 0.91 | ESR2 (0.47) | MKNK1ESR2CYP3A4CYP3A5NR1H2 | |
| SCHEMBL31413139 | 0.91 | ESR2 (0.47) | MKNK1ESR2CYP3A4CYP3A5NR1H2 | |
| SCHEMBL30474218 | 0.90 | ESR2 (0.44) | MKNK1ESR2CYP3A4CYP3A5NR1H2 | |
| SCHEMBL31413097 | 0.90 | ESR2 (0.44) | MKNK1ESR2CYP3A4CYP3A5NR1H2 | |
| SCHEMBL30474097 | 0.90 | ESR2 (0.44) | MKNK1ESR2CYP3A4CYP3A5NR1H2 | |
| SCHEMBL31413077 | 0.90 | ESR2 (0.44) | MKNK1ESR2CYP3A4CYP3A5NR1H2 | |
| SCHEMBL31413089 | 0.90 | ESR2 (0.44) | MKNK1ESR2CYP3A4CYP3A5NR1H2 | |
| SCHEMBL30474105 | 0.90 | ESR2 (0.44) | MKNK1ESR2CYP3A4CYP3A5NR1H2 | |
| SCHEMBL31413098 | 0.90 | ESR2 (0.44) | MKNK1ESR2CYP3A4CYP3A5NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250109148-A1 | HETEROCYCLIC GLP-1 AGONISTS | SHANGHAI SHOUTI BIOTECHNOLOGY CO., LTD. (CN) | 2025-04-03 | — | — | US | disclosed |
| CN-119343339-A | Heterocyclic GLP-1 agonists | 加舒布鲁姆生物公司 | 2025-01-21 | — | — | CN | disclosed |
| EP-4469444-A1 | HETEROCYCLIC GLP-1 AGONISTS | Gasherbrum Bio, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023138684-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO , INC. (US) | 2023-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250109148-A1 | HETEROCYCLIC GLP-1 AGONISTS | GLP1R, GIPR, GCGR | MKNK1 1729/4885ESR2 447/4885CYP3A4 2070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.