Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.34 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25031313 | 1.00 | CRBN (0.43) | CRBNDDB1POLBIKZF3GSPT1 | |
| SCHEMBL26641341 | 1.00 | CRBN (0.43) | CRBNDDB1POLBIKZF3GSPT1 | |
| SCHEMBL26641269 | 0.88 | CRBN (0.44) | CRBNDDB1POLBIKZF3GSPT1 | |
| SCHEMBL30643676 | 0.88 | CRBN (0.44) | CRBNDDB1POLBIKZF3GSPT1 | |
| SCHEMBL24670689 | 0.87 | CRBN (0.44) | CRBNDDB1POLBGSPT1 | |
| SCHEMBL25035146 | 0.86 | FFAR4 (0.44) | CRBNDDB1 | |
| SCHEMBL24671220 | 0.86 | CRBN (0.45) | CRBNDDB1POLBIKZF3DRD2 | |
| SCHEMBL30066283 | 0.86 | CRBN (0.45) | CRBNDDB1POLBIKZF3DRD2 | |
| SCHEMBL27194319 | 0.86 | CRBN (0.45) | CRBNDDB1POLBIKZF3DRD2 | |
| SCHEMBL25031309 | 0.85 | CRBN (0.43) | CRBNDDB1POLBGSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120092003-A | CDK protein degrading agents, pharmaceutical compositions and therapeutic uses | 拜欧斯瑞克斯公司 | 2025-06-03 | — | — | CN | disclosed |
| WO-2024208256-A1 | TARGETED PROTEIN DEGRADATION COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海汇伦医药股份有限公司 | 2024-10-10 | — | — | WO | disclosed |
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| WO-2023220640-A1 | CDK PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |