Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 1.00 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 5/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 2/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372771 | 1.00 | TOP1 (1.00) | TOP1CSNK2A1MALT1BRCA1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29914031 | 0.99 | TOP1 (0.98) | TOP1CSNK2A1MALT1BRCA1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1333536 | 0.99 | TOP1 (0.98) | TOP1CSNK2A1MALT1BRCA1SMN1; SMN2 | |
| SCHEMBL26843508 | 0.88 | TOP1 (0.78) | TOP1CSNK2A1MALT1BRCA1SMN1; SMN2 | |
| SCHEMBL5782011 | 0.88 | TOP1 (0.78) | TOP1CSNK2A1SMN1; SMN2TOP2ACSNK2A2 | |
| SCHEMBL5785230 | 0.88 | TOP1 (0.78) | TOP1CSNK2A1BRCA1SMN1; SMN2HIF1A | |
| Hydrochloric Acid SCHEMBL7823442 | 0.86 | TOP1 (0.76) | TOP1CSNK2A1MALT1BRCA1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7812716 | 0.86 | TOP1 (0.75) | TOP1CSNK2A1 | |
| SCHEMBL7810923 | 0.85 | TOP1 (0.74) | TOP1CSNK2A1MALT1TOP2AEHMT2 | |
| SCHEMBL3257092 | 0.85 | TOP1 (0.74) | TOP1CSNK2A1BRCA1SMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2041 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230045112-A1 | DISULFIRAM AND OTHER REDOX-RELATED COMPOSITIONS FOR BRAIN TUMORS | TEXAS TECH UNIVERSITY SYSTEM | 2023-02-09 | — | — | US | claimed |
| EP-2805945-B1 | Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors | MSD ITALIA SRL (IT) | 2019-04-03 | — | — | EP | claimed |
| EP-2603222-B1 | COMBINATORY CANCER TREATMENT | UNIV MONTREAL (CA) | 2018-10-17 | — | — | EP | claimed |
| US-20160346231-A1 | Disulfiram Compositions and Treatments for Brain Tumors | TEXAS TECH UNIVERSITY SYSTEM | 2016-12-01 | — | — | US | claimed |
| US-20140301976-A1 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS | PHARMACYCLICS, INC. | 2014-10-09 | — | — | US | claimed |
| US-8779171-B2 | Hydroxamates as therapeutic agents | PHARMACYCLICS, INC. (US) | 2014-07-15 | — | — | US | claimed |
| US-20130209578-A1 | Combinatory Cancer Treatment | UNIVERSITE DE MONTREAL (CA) | 2013-08-15 | — | — | US | claimed |
| EP-2603222-A1 | COMBINATORY CANCER TREATMENT | UNIVERSITE DE MONTREAL (CA) | 2013-06-19 | — | — | EP | claimed |
| US-20130142758-A1 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS | PHARMACYCLICS, INC. (US) | 2013-06-06 | — | — | US | claimed |
| WO-2012019284-A1 | COMBINATORY CANCER TREATMENT | UNIVERSITE DE MONTREAL (CA) | 2012-02-16 | — | — | WO | claimed |
| EP-1121102-B1 | LIPOSOME-ENTRAPPED TOPOISOMERASE INHIBITORS | ALZA CORP (US) | 2003-04-23 | — | — | EP | claimed |
| US-20260132164-A1 | PNU ANTHRACYCLINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2026-05-14 | — | — | US | disclosed |
| EP-4076459-B1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2026-04-29 | — | — | EP | disclosed |
| US-12595262-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-04-07 | — | — | US | disclosed |
| US-12595248-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-04-07 | — | — | US | disclosed |
| WO-2001017995-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |
| US-6028079-A | FOR TREATING TUMOR OF MAMMAL | TAIHO PHARMACEUTICAL CO., LTD (JP) | 2000-02-22 | — | — | US | disclosed |
| US-5733918-A | ANTITUMOR AGENT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1998-03-31 | — | — | US | disclosed |
| US-5710162-A | ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0713870-A1 | NOVEL FUSED INDAN DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1996-05-29 | — | — | EP | disclosed |