Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.72 |
| ▸ | JAK1 | P23458 | 11/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.72 |
| ▸ | JAK3 | P52333 | 5/20 | 0.72 |
| ▸ | TYK2 | P29597 | 4/20 | 0.72 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.72 |
| ▸ | PAK4 | O96013 | 2/20 | 0.72 |
| ▸ | ABL1 | P00519 | 2/20 | 0.72 |
| ▸ | RET | P07949 | 2/20 | 0.72 |
| ▸ | LTK | P29376 | 2/20 | 0.72 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.72 |
| ▸ | CLK2 | P49760 | 2/20 | 0.72 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.72 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.72 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.72 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.72 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.72 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.72 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.72 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30846778 | 1.00 | JAK2 (0.72) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL19098146 | 1.00 | JAK2 (0.72) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL19098148 | 1.00 | JAK2 (0.72) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL19098145 | 0.92 | JAK2 (0.72) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL20548737 | 0.92 | JAK2 (0.72) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL30480817 | 0.92 | JAK2 (0.72) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL19098144 | 0.91 | JAK2 (0.70) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL25815273 | 0.90 | JAK2 (0.68) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL31281026 | 0.89 | JAK2 (0.57) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL24505546 | 0.86 | JAK2 (0.74) | JAK2JAK1HDAC6JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240122858-A1 | MODIFIED-RELEASE DOSAGE FORMS OF RUXOLITINIB | SLAYBACK PHARMA LLC (NJ) | 2024-04-18 | — | — | US | disclosed |
| US-20230172863-A1 | MODIFIED-RELEASE DOSAGE FORMS OF RUXOLITINIB | ARBOR PHARMACEUTICALS, LLC | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230172863-A1 | MODIFIED-RELEASE DOSAGE FORMS OF RUXOLITINIB | JAK1, JAK3, JAK2 | JAK2 3/4885JAK1 1/4885HDAC6 2820/4885 |
| US-20240122858-A1 | MODIFIED-RELEASE DOSAGE FORMS OF RUXOLITINIB | JAK1, JAK3, JAK2 | JAK2 3/4885JAK1 1/4885HDAC6 2443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.