Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 7/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316892 | 1.00 | FGFR2 (0.36) | FGFR2FGFR3FGFR1FGFR4KDR | |
| SCHEMBL24316602 | 0.86 | CREBBP (0.40) | FGFR2FGFR3FGFR1FGFR4USP30 | |
| SCHEMBL29471215 | 0.86 | CREBBP (0.40) | FGFR2FGFR3FGFR1FGFR4USP30 | |
| SCHEMBL29471144 | 0.86 | RET (0.39) | FGFR2FGFR3FGFR1USP30KDM4E | |
| SCHEMBL24316782 | 0.86 | RET (0.39) | FGFR2FGFR3FGFR1USP30KDM4E | |
| SCHEMBL24316691 | 0.85 | USP30 (0.39) | FGFR2FGFR3FGFR1FGFR4KDR | |
| SCHEMBL29471235 | 0.85 | USP30 (0.39) | FGFR2FGFR3FGFR1FGFR4KDR | |
| SCHEMBL24316889 | 0.83 | USP30 (0.38) | FGFR2FGFR3FGFR1USP30ATM | |
| SCHEMBL24316769 | 0.82 | FGFR1 (0.38) | FGFR2FGFR3FGFR1USP30ATM | |
| SCHEMBL26548319 | 0.82 | ATM (0.36) | FGFR2FGFR3FGFR1FGFR4USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116368128-A | Heterocyclic compounds as CBP/EP300 bromodomain inhibitors | 奥瑞基尼肿瘤有限公司 | 2023-06-30 | — | — | CN | disclosed |