Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14608982 | 1.00 | MAPT (0.58) | MAPTKDM4ETHRBTDP1HSD17B10 | |
| SCHEMBL8546761 | 1.00 | MAPT (0.58) | MAPTKDM4ETHRBTDP1HSD17B10 | |
| SCHEMBL25379010 | 0.92 | MAPT (0.51) | MAPTKDM4ETHRBTDP1HSD17B10 | |
| SCHEMBL5588598 | 0.81 | CA12 (0.53) | MAPTKDM4EHSD17B10ALDH1A1POLB | |
| SCHEMBL5693725 | 0.81 | CA12 (0.53) | MAPTKDM4EHSD17B10ALDH1A1POLB | |
| SCHEMBL5590740 | 0.78 | CA12 (0.56) | MAPTKDM4ETDP1HSD17B10GAA | |
| SCHEMBL5693805 | 0.78 | CA12 (0.56) | MAPTKDM4ETDP1HSD17B10GAA | |
| SCHEMBL474244 | 0.75 | GRIN2D (0.51) | MAPTKDM4EHSD17B10GAAALDH1A1 | |
| SCHEMBL474245 | 0.75 | GRIN2D (0.51) | MAPTKDM4EHSD17B10GAAALDH1A1 | |
| SCHEMBL27778326 | 0.75 | GRIN2D (0.51) | MAPTKDM4EHSD17B10GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469438-A1 | COMPOUNDS AND METHODS OF USE | Tango Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |