SCHEMBL30486188

SCHEMBL30486188

N#Cc1ccccc1C#CBr

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.48
CA1 P00915 2/20 0.39
CA2 P00918 2/20 0.39
ESR2 Q92731 1/20 0.39
MAOA P21397 3/20 0.38
MAOB P27338 3/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
MCL1 Q07820 1/20 0.37
HTT P42858 2/20 0.36
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
LMNA P02545 2/20 0.36
THRB P10828 1/20 0.36
IMPDH2 P12268 1/20 0.35
IMPDH1 P20839 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28269441 0.86 TSHR (0.60) TSHRCA1CA2ESR2MAOA
Water SCHEMBL27896186 0.83 TSHR (0.63) TSHRCA1CA2ESR2MAOA
Water SCHEMBL19410621 0.83 TSHR (0.63) TSHRCA1CA2ESR2MAOA
SCHEMBL2818597 0.83 TSHR (0.63) TSHRCA1CA2ESR2MAOA
SCHEMBL29352197 0.83 TSHR (0.63) TSHRCA1CA2ESR2MAOA
SCHEMBL57480 0.83 TSHR (0.63) TSHRCA1CA2ESR2MAOA
Hydrogen Sulfide SCHEMBL1324202 0.80 TSHR (0.60) TSHRCA1CA2ESR2MAOA
Methane SCHEMBL18035842 0.80 TSHR (0.60) TSHRCA1CA2ESR2MAOA
SCHEMBL3959857 0.80 TSHR (0.60) TSHRCA1CA2ESR2MAOA
SCHEMBL10899986 0.80 TSHR (0.60) TSHRCA1CA2ESR2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116425668-A Carbazole derivative and application thereof 北京八亿时空液晶科技股份有限公司 2023-07-14 CN disclosed