Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mln-0415. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB known ✓ | O14920 | 1/20 | 0.43 |
| ▸ | ICOSLG | O75144 | 11/20 | 0.59 |
| ▸ | ICOS | Q9Y6W8 | 11/20 | 0.59 |
| ▸ | CHUK | O15111 | 15/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mln-0415 SCHEMBL13270227 | 1.00 | ICOSLG (0.59) | ICOSLGICOSCHUKMEN1IKBKB | |
| Mln-0415 SCHEMBL12619680 | 1.00 | ICOSLG (0.59) | ICOSLGICOSCHUKMEN1IKBKB | |
| Mln-0415 SCHEMBL3805697 | 1.00 | ICOSLG (0.59) | ICOSLGICOSCHUKMEN1IKBKB | |
| Mln-0415 SCHEMBL3805703 | 1.00 | ICOSLG (0.59) | ICOSLGICOSCHUKMEN1IKBKB | |
| Mln-0415 SCHEMBL12619648 | 1.00 | ICOSLG (0.59) | ICOSLGICOSCHUKMEN1IKBKB | |
| Mln-0415 SCHEMBL1798964 | 1.00 | ICOSLG (0.59) | ICOSLGICOSCHUKMEN1IKBKB | |
| Mln-0415 SCHEMBL3809102 | 0.99 | ICOSLG (0.58) | ICOSLGICOSCHUKMEN1IKBKB | |
| Mln-0415 SCHEMBL3809130 | 0.97 | ICOSLG (0.56) | ICOSLGICOSCHUKMEN1IKBKB | |
| Mln-0415 SCHEMBL3812928 | 0.97 | ICOSLG (0.56) | ICOSLGICOSCHUKMEN1IKBKB | |
| Mln-0415 SCHEMBL3812933 | 0.97 | ICOSLG (0.56) | ICOSLGICOSCHUKMEN1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4460301-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | Universität zu Köln (DE) | 2024-11-13 | — | — | EP | claimed |
| WO-2023131576-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | UNIVERSITÄT ZU KÖLN (DE) | 2023-07-13 | — | — | WO | claimed |
| EP-4460301-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | Universität zu Köln (DE) | 2024-11-13 | — | — | EP | disclosed |
| WO-2023131576-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | UNIVERSITÄT ZU KÖLN (DE) | 2023-07-13 | — | — | WO | disclosed |
| EP-4209213-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | Universität zu Köln (DE) | 2023-07-12 | — | — | EP | disclosed |