Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.46 |
| ▸ | IKZF3 | Q9UKT9 | 16/20 | 0.46 |
| ▸ | TNF | P01375 | 3/20 | 0.40 |
| ▸ | IL1B | P01584 | 3/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257096 | 1.00 | CRBN (0.46) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL29790878 | 0.92 | CRBN (0.45) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL2249389 | 0.92 | CRBN (0.45) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL30493790 | 0.92 | CRBN (0.45) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL2249437 | 0.92 | CRBN (0.45) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL26321489 | 0.91 | CRBN (0.47) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL26317758 | 0.91 | CRBN (0.47) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL2249958 | 0.91 | CRBN (0.45) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL2246785 | 0.90 | CRBN (0.55) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL2251428 | 0.90 | CRBN (0.46) | CRBNIKZF3TNFIL1BDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4289838-A2 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2023-12-13 | — | — | EP | disclosed |
| EP-3599236-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2023-08-23 | — | — | EP | disclosed |