Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.72 |
| ▸ | IKZF3 | Q9UKT9 | 18/20 | 0.72 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.70 |
| ▸ | DRD2 | P14416 | 1/20 | 0.70 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.70 |
| ▸ | TNF | P01375 | 3/20 | 0.68 |
| ▸ | IL1B | P01584 | 3/20 | 0.68 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2249118 | 1.00 | CRBN (0.72) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL16768369 | 0.93 | CRBN (0.62) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL2248510 | 0.93 | CRBN (0.78) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL30493674 | 0.90 | CRBN (0.78) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL2250247 | 0.90 | CRBN (0.78) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL19222232 | 0.87 | CRBN (0.68) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL2252296 | 0.86 | CRBN (0.91) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL26318062 | 0.86 | CRBN (0.91) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL26321494 | 0.86 | CRBN (0.91) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL2251019 | 0.86 | CRBN (0.79) | CRBNIKZF3DDB1DRD2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3599236-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2023-08-23 | — | — | EP | disclosed |