Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | CBS | P35520 | 1/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 9/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 6/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | CLK1 | P49759 | 7/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.41 |
| ▸ | CLK2 | P49760 | 5/20 | 0.41 |
| ▸ | DYRK4 | Q9NR20 | 4/20 | 0.41 |
| ▸ | CLK3 | P49761 | 3/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26096313 | 1.00 | MAPT (0.57) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL26107614 | 0.81 | MAPT (0.61) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30363432 | 0.78 | MAPT (0.60) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL26094464 | 0.78 | MAPT (0.56) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL26106872 | 0.78 | MAPT (0.60) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30494190 | 0.78 | MAPT (0.56) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL26096339 | 0.78 | MAPT (0.56) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30396066 | 0.78 | MAPT (0.56) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL26092399 | 0.78 | MAPT (0.56) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30363334 | 0.77 | MAPT (0.55) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |