Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | IDH1 | O75874 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CBS | P35520 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | PRF1 | P14222 | 3/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23510560 | 1.00 | CSNK2A2 (0.56) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL30363450 | 0.79 | CSNK2A2 (0.64) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL24904264 | 0.79 | CSNK2A2 (0.64) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL30494037 | 0.77 | IDH1 (0.58) | MEN1KMT2AIDH1MAPTALDH1A1 | |
| SCHEMBL23510685 | 0.75 | DYRK1A (0.81) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL24904485 | 0.75 | MEN1 (0.67) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL24904312 | 0.73 | CSNK2A2 (0.56) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL30494235 | 0.73 | MEN1 (0.60) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL24904549 | 0.72 | MEN1 (0.63) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL23499923 | 0.72 | CLK1 (1.00) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |