Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL22584608 | 0.93 | PTPN11 (0.44) | PTPN11KCNH2 | |
| SCHEMBL25810605 | 0.82 | PTPN11 (0.52) | PTPN11 | |
| SCHEMBL20899408 | 0.80 | PTPN11 (0.56) | PTPN11 | |
| SCHEMBL16914390 | 0.79 | PTPN11 (0.73) | PTPN11 | |
| SCHEMBL16925308 | 0.79 | PTPN11 (0.73) | PTPN11 | |
| SCHEMBL24879054 | 0.79 | PTPN11 (0.38) | PTPN11KCNH2 | |
| SCHEMBL30295766 | 0.74 | PTPN11 (0.56) | PTPN11KCNH2 | |
| SCHEMBL19785034 | 0.74 | PTPN11 (0.56) | PTPN11KCNH2 | |
| SCHEMBL23160727 | 0.74 | PTPN11 (0.56) | PTPN11KCNH2 | |
| SCHEMBL16925245 | 0.74 | PTPN11 (0.60) | PTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067636-A1 | PYRIDINE, PYRAZINE, AND TRIAZINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. | 2024-02-29 | — | — | US | disclosed |
| US-11702411-B2 | Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors | Revolution Medicines, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067636-A1 | PYRIDINE, PYRAZINE, AND TRIAZINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS | PTPN5, PTPN2, PTPN1 | PTPN11 6/4885KCNH2 3400/4885 |
| US-11702411-B2 | Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors | PTPN5, PTPN2, PTPN1 | PTPN11 6/4885KCNH2 3400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.