Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.64 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | G6PD | P11413 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.58 |
| ▸ | PARP3 | Q9Y6F1 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29040111 | 1.00 | PARP1 (0.64) | PARP1PARP2HDAC3HDAC4HDAC1 | |
| SCHEMBL30495504 | 0.99 | PARP1 (0.65) | PARP1PARP2HDAC3HDAC4HDAC1 | |
| SCHEMBL29040068 | 0.95 | PARP1 (0.67) | PARP1PARP2TP53G6PDPDE10A | |
| SCHEMBL29040039 | 0.90 | PARP1 (0.74) | PARP1PARP2PARP3SMN1; SMN2RECQL | |
| SCHEMBL721483 | 0.84 | HDAC3 (0.70) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL718972 | 0.84 | HDAC3 (0.70) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL29040046 | 0.84 | PARP1 (0.62) | PARP1PARP2TP53G6PDPDE10A | |
| SCHEMBL29040009 | 0.84 | PARP1 (0.62) | PARP1PARP2TP53G6PDPDE10A | |
| SCHEMBL29040127 | 0.83 | HDAC1 (0.60) | PARP1PARP2HDAC3HDAC4HDAC1 | |
| SCHEMBL30495476 | 0.83 | HDAC1 (0.60) | PARP1PARP2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116496224-B | 4-Quinazolinone hydroxamic acid derivative, pharmaceutical composition and application thereof | 武汉思瓴生物科技有限公司 | 2024-11-01 | — | — | CN | disclosed |
| CN-116496224-A | 4-quinazolinone hydroxamic acid derivative, pharmaceutical composition and application thereof | 武汉思瓴生物科技有限公司 | 2023-07-28 | — | — | CN | disclosed |