⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423524 | 0.65 | — | — | |
| SCHEMBL977424 | 0.56 | — | — | |
| Ammonia Solution, Strong SCHEMBL19859642 | 0.53 | — | — | |
| SCHEMBL715867 | 0.51 | GSK3B (1.00) | — | |
| SCHEMBL10990 | 0.51 | — | — | |
| SCHEMBL33524954 | 0.51 | — | — | |
| SCHEMBL616019 | 0.51 | — | — | |
| SCHEMBL7655677 | 0.50 | — | — | |
| SCHEMBL28083309 | 0.50 | GSK3A (0.73) | — | |
| Charcoal, Activated SCHEMBL4128314 | 0.49 | GSK3A (0.92) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7648959-B2 | Methods and compositions for the treatment of diseases of the eye | MERCK PATENT GMBH (DE) | 2010-01-19 | — | — | US | claimed |
| US-7645736-B2 | injecting an alpha-v. beta 3 or alpha-v, beta 5 inhibitor into the vitreous body of the eye; angiogenesis inhibition; diabetic retinopathy, macular degeneration, myopia, ocular histoplasmosis; (2S)-2-benzyloxycarboxamido-3-(2-guanidinomethyl-1,4-benzodioxan-6-yl)propionic acid | MERCK PATENT GMBH (DE) | 2010-01-12 | — | — | US | claimed |
| EP-1594853-B1 | METHOD FOR THE PRODUCTION OF BICYCLIC AROMATIC AMINO ACIDS AND INTERMEDIATE PRODUCTS THEREOF | MERCK PATENT GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| US-7371854-B2 | Method for the production of bicyclic aromatic amino acids and intermediate products thereof | MERCK PATENT GMBH (DE) | 2008-05-13 | — | — | US | claimed |
| US-20060287225-A1 | Integrin inhibitors for the treatment of eye diseases | SCRIPPS RESEARCH INSTITUTE, THE | 2006-12-21 | — | — | US | claimed |
| US-20060223746-A1 | Methods and compositions for the treatment of diseases of the eye | SCRIPPS RESEARCH INSTITUTE, THE | 2006-10-05 | — | — | US | claimed |
| US-20060142568-A1 | Method for the production of bicyclic aromatic amino acids and intermediate products thereof | MEREK PATENT GMBH (DE) | 2006-06-29 | — | — | US | claimed |
| EP-1411926-B1 | INTEGRIN INHIBITORS FOR THE TREATMENT OF EYE DISEASES | MERCK PATENT GMBH (DE) | 2005-06-01 | — | — | EP | claimed |
| US-20050085415-A1 | Methods and compositions for the treatment of eye diseases | MERCK PATENT GMBH (DE) | 2005-04-21 | — | — | US | claimed |
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | claimed |
| EP-1474162-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISEASES | MERCK PATENT GmbH (DE) | 2004-11-10 | — | — | EP | claimed |
| US-20040198644-A1 | Integrin inhibitors for the treatment of eye diseases | MERCK PATENT GESELLSCHAFT (DE) | 2004-10-07 | — | — | US | claimed |
| EP-1411926-A1 | INTEGRIN INHIBITORS FOR THE TREATMENT OF EYE DISEASES | MERCK PATENT GmbH (DE) | 2004-04-28 | — | — | EP | claimed |
| US-20040029788-A1 | Methods and compositions for the treatment of diseases of the eye | MERCK PATENT GMBH (DE) | 2004-02-12 | — | — | US | claimed |
| EP-1381382-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES OF THE EYE | MERCK PATENT GmbH (DE) | 2004-01-21 | — | — | EP | claimed |
| WO-2003068253-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISEASES | MERCK PATENT GMBH (DE) | 2003-08-21 | — | — | WO | claimed |
| WO-2003013511-A1 | INTEGRIN INHIBITORS FOR THE TREATMENT OF EYE DISEASES | MERCK PATENT GMBH (DE) | 2003-02-20 | — | — | WO | claimed |
| US-6521646-B1 | Integrin inhibitors | MERCK PATENT GMBH (DE) | 2003-02-18 | — | — | US | claimed |
| EP-0964856-B1 | BICYCLIC AMINO ACIDS | MERCK PATENT GMBH (DE) | 2002-10-09 | — | — | EP | claimed |
| WO-2002041910-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES OF THE EYE | MERCK PATENT GMBH (DE) | 2002-05-30 | — | — | WO | claimed |