SCHEMBL30498463

SCHEMBL30498463

[2H]C([2H])([2H])Oc1c(Br)ccc2cnn(C(C)C)c12

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
NPBWR1 P48145 1/20 0.30
MCHR1 Q99705 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25240140 0.90 NQO2 (0.36) HTR2AHTR2CNPBWR1MCHR1
SCHEMBL30498456 0.83 HTR2A (0.36) HTR2AHTR2C
SCHEMBL30498391 0.77 HASPIN (0.35) HTR2AHTR2CNPBWR1
SCHEMBL31017412 0.76 NQO2 (0.33) HTR2AHTR2CNPBWR1MCHR1
SCHEMBL25757759 0.75 HTR2A (0.34) HTR2AHTR2C
SCHEMBL30498134 0.75 HTR2A (0.32) HTR2AHTR2C
SCHEMBL30498257 0.75 LRRK2 (0.33)
SCHEMBL30498065 0.72 NQO2 (0.36) HTR2AHTR2C
SCHEMBL25240844 0.72 HTR2A (0.41) HTR2AHTR2CMCHR1
SCHEMBL30895051 0.71 PIK3CD (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4448514-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF Lynk Pharmaceuticals Co. Ltd. (CN) 2024-10-23 EP disclosed
WO-2023109954-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2023-06-22 WO disclosed