Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25291420 | 1.00 | CYP11B1 (0.42) | CYP11B1CYP11B2HRH3MEN1KMT2A | |
| SCHEMBL30499175 | 0.81 | GCK (0.33) | HRH3MEN1KMT2AGCK | |
| SCHEMBL25250601 | 0.81 | GCK (0.33) | HRH3MEN1KMT2AGCK | |
| SCHEMBL31093829 | 0.80 | CYP11B1 (0.46) | CYP11B1CYP11B2 | |
| SCHEMBL25298008 | 0.78 | GCK (0.39) | GCK | |
| SCHEMBL25252981 | 0.74 | TLR7 (0.40) | GCK | |
| SCHEMBL31303079 | 0.74 | TLR7 (0.40) | GCK | |
| SCHEMBL22978656 | 0.74 | CYP11B1 (0.47) | CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL27842672 | 0.74 | CYP11B1 (0.40) | CYP11B1CYP11B2KMT2A | |
| SCHEMBL19835322 | 0.73 | CYP11B1 (0.50) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119013265-A | GLUT9 heterocyclic inhibitors for the treatment of disease | 爱尔兰好利恩治疗有限公司 | 2024-11-22 | — | — | CN | disclosed |
| EP-4460496-A1 | HETEROCYCLIC INHIBITORS OF GLUT9 FOR TREATMENT OF DISEASE | Horizon Therapeutics Ireland DAC (IE) | 2024-11-13 | — | — | EP | disclosed |
| WO-2023131868-A1 | HETEROCYCLIC INHIBITORS OF GLUT9 FOR TREATMENT OF DISEASE | HORIZON THERAPEUTICS IRELAND DAC (IE) | 2023-07-13 | — | — | WO | disclosed |