Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.70 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.68 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | CA7 | P43166 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130116 | 0.95 | CYP4A11 (0.71) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL6389650 | 0.89 | CYP4A11 (0.64) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL570747 | 0.88 | ESR1 (0.59) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL12199135 | 0.87 | CA1 (0.68) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10610630 | 0.86 | CA12 (0.58) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL570964 | 0.86 | RARB (0.58) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL15122388 | 0.85 | CYP4A11 (0.58) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL1701986 | 0.85 | CYP4A11 (0.58) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL9045556 | 0.85 | CA12 (0.53) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL25340300 | 0.85 | SMN1; SMN2 (0.69) | CYP4A11CYP4F2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261914-A1 | IAP BINDING COMPOUNDS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261914-A1 | IAP BINDING COMPOUNDS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261914-A1 | IAP BINDING COMPOUNDS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2010-10-14 | — | — | US | disclosed |
| US-7718600-B2 | IAP binding compounds | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718600-B2 | IAP binding compounds | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718600-B2 | IAP binding compounds | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| EP-1578777-B1 | IAP BINDING COMPOUNDS | UNIV PRINCETON (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-1578777-B1 | IAP BINDING COMPOUNDS | UNIV PRINCETON (US) | 2008-11-26 | — | — | EP | disclosed |
| US-20080004274-A1 | Novel biaromatic compounds that modulate PPAR type receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-01-03 | — | — | US | disclosed |
| US-20080004274-A1 | Novel biaromatic compounds that modulate PPAR type receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-01-03 | — | — | US | disclosed |
| EP-1828124-A1 | BIAROMATIC COMPOUNDS THAT MODULATE PPAR TYPE RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | Galderma Research & Development (FR) | 2007-09-05 | — | — | EP | disclosed |
| US-20070032437-A1 | that bind cellular inhibitor of apoptosis proteins; drug design and development for diagnosis, prevention and treatment of cell proliferative disease; anticarcinogenic agents | THE TRUSTEES OF PRINCETON UNIVERSITY | 2007-02-08 | — | — | US | disclosed |
| US-20070032437-A1 | that bind cellular inhibitor of apoptosis proteins; drug design and development for diagnosis, prevention and treatment of cell proliferative disease; anticarcinogenic agents | THE TRUSTEES OF PRINCETON UNIVERSITY | 2007-02-08 | — | — | US | disclosed |
| US-20070032437-A1 | that bind cellular inhibitor of apoptosis proteins; drug design and development for diagnosis, prevention and treatment of cell proliferative disease; anticarcinogenic agents | THE TRUSTEES OF PRINCETON UNIVERSITY | 2007-02-08 | — | — | US | disclosed |
| EP-1578777-A4 | IAP BINDING COMPOUNDS | UNIV PRINCETON (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2006063863-A1 | BIAROMATIC COMPOUNDS THAT MODULATE PPAR TYPE RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2006-06-22 | — | — | WO | disclosed |
| EP-1578777-A2 | IAP BINDING COMPOUNDS | The Trustees of Princeton University (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004007529-A2 | IAP BINDING COMPOUNDS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2004-01-22 | — | — | WO | disclosed |
| EP-0162208-B1 | NOVEL N-SUBSTITUTED 3,4-DIHYDROPYRIMIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS | SUNTORY KABUSHIKI KAISHA, also known as SUNTORY LTD. (JP) | 1989-11-23 | — | — | EP | disclosed |
| US-4683234-A | HYPOTENSIVE AGENTS, ANTI-ANGINA | SUNTORY LIMITED (JP) | 1987-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032437-A1 | that bind cellular inhibitor of apoptosis proteins; drug design and development for diagnosis, prevention and treatment of cell proliferative disease; anticarcinogenic agents | BIRC3, API5, BID | CYP4A11 4831/4885CYP4F2 4292/4885CA12 3086/4885 |
| US-20080004274-A1 | Novel biaromatic compounds that modulate PPAR type receptors and cosmetic/pharmaceutical compositions comprised thereof | PPARG, PPARD, PPARA | CYP4A11 293/4885CYP4F2 445/4885CA12 4873/4885 |
| US-20100261914-A1 | IAP BINDING COMPOUNDS | BIRC3, BIRC5, BIRC2 | CYP4A11 4860/4885CYP4F2 4683/4885CA12 4357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.