Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.65 |
| ▸ | CSF1R | P07333 | 5/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20598247 | 1.00 | IRAK4 (0.65) | IRAK4CSF1RIRAK1HDAC6ROCK2 | |
| SCHEMBL20598535 | 0.94 | IRAK4 (0.65) | IRAK4CSF1RIRAK1HDAC6ROCK2 | |
| SCHEMBL20598567 | 0.93 | IRAK4 (0.66) | IRAK4IRAK1HDAC6ROCK2ROCK1 | |
| SCHEMBL20598451 | 0.89 | IRAK4 (0.63) | IRAK4IRAK1ROCK2ROCK1PIM1 | |
| SCHEMBL20598483 | 0.88 | IRAK4 (0.65) | IRAK4IRAK1HDAC6PIM1PIM3 | |
| SCHEMBL20597967 | 0.88 | IRAK4 (0.66) | IRAK4IRAK1ROCK2ROCK1PIM1 | |
| SCHEMBL20598453 | 0.87 | IRAK4 (0.61) | IRAK4IRAK1ROCK2ROCK1PIM1 | |
| SCHEMBL20597981 | 0.87 | IRAK4 (0.66) | IRAK4CSF1RHDAC6ROCK2ROCK1 | |
| SCHEMBL20598190 | 0.86 | IRAK4 (0.72) | IRAK4IRAK1PIM1PIM3 | |
| SCHEMBL20598308 | 0.86 | CHEK1 (0.55) | IRAK4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |