Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | SYK | P43405 | 7/20 | 0.57 |
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30504139 | 1.00 | EGFR (0.60) | EGFRERBB2SYKDHODHJAK2 | |
| SCHEMBL22401298 | 1.00 | EGFR (0.60) | EGFRERBB2SYKDHODHJAK2 | |
| SCHEMBL14607400 | 0.89 | EGFR (0.61) | EGFRERBB2SYKDHODHJAK2 | |
| SCHEMBL6644053 | 0.86 | SYK (0.67) | EGFRERBB2SYKDHODHJAK2 | |
| SCHEMBL2627315 | 0.83 | SYK (0.60) | SYKDHODHNPSR1MEN1KMT2A | |
| SCHEMBL4713013 | 0.81 | SYK (0.67) | SYKNPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2627263 | 0.80 | SYK (0.58) | SYKNPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL656113 | 0.80 | SYK (0.58) | EGFRERBB2SYKNPSR1MEN1 | |
| SCHEMBL2627347 | 0.80 | SYK (0.60) | SYKNPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL655545 | 0.80 | SYK (0.59) | SYKNPSR1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527084-B | Isofuranone compounds useful as HPK1 inhibitors | 百时美施贵宝公司 | 2023-07-18 | — | — | CN | disclosed |