Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.55 |
| ▸ | JAK2 | O60674 | 5/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | FLT1 | P17948 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | CLK2 | P49760 | 3/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.55 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.55 |
| ▸ | RET | P07949 | 3/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.55 |
| ▸ | PAK4 | O96013 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | LTK | P29376 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1585071 | 1.00 | DYRK1A (0.55) | DYRK1ADYRK1BJAK2AURKAMAP4K4 | |
| SCHEMBL1585882 | 0.78 | DYRK1B (0.44) | DYRK1ADYRK1BJAK2AURKAMAP4K4 | |
| SCHEMBL16537147 | 0.78 | DYRK1B (0.44) | DYRK1ADYRK1BJAK2AURKAMAP4K4 | |
| SCHEMBL1144888 | 0.78 | DYRK1B (0.44) | DYRK1ADYRK1BJAK2AURKAMAP4K4 | |
| SCHEMBL1592867 | 0.78 | DYRK1B (0.44) | DYRK1ADYRK1BJAK2AURKAMAP4K4 | |
| SCHEMBL1585981 | 0.78 | DYRK1A (0.45) | DYRK1ADYRK1BJAK2AURKAMAP4K4 | |
| SCHEMBL3373929 | 0.77 | DYRK1B (0.43) | DYRK1ADYRK1BJAK2AURKAMAP4K4 | |
| SCHEMBL12466822 | 0.76 | IDO1 (0.46) | DYRK1ADYRK1BJAK2AURKAMAP4K4 | |
| SCHEMBL30440210 | 0.76 | RET (0.38) | DYRK1AJAK2RETLRRK2PDPK1 | |
| SCHEMBL22582281 | 0.76 | IDO1 (0.46) | DYRK1AJAK2KDRRETLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478145-B | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116478145-A | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-07-25 | — | — | CN | disclosed |