Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | FYN | P06241 | 3/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29041952 | 1.00 | PDGFRB (0.56) | PDGFRBKDRCHEK2MAP4K4CHEK1 | |
| SCHEMBL16679826 | 0.84 | PDGFRB (0.44) | PDGFRBKDRCHEK2MAP4K4CHEK1 | |
| SCHEMBL26916995 | 0.84 | FYN (0.52) | CHEK2MAP4K4CHEK1FYNMKNK1 | |
| SCHEMBL12516834 | 0.82 | FYN (0.69) | CHEK2MAP4K4CHEK1FYNMKNK1 | |
| SCHEMBL16679304 | 0.81 | MAPK1 (0.46) | PDGFRBKDR | |
| SCHEMBL22554101 | 0.81 | CHEK2 (0.62) | CHEK2MAP4K4CHEK1FYNMKNK1 | |
| SCHEMBL17668204 | 0.80 | PDGFRB (0.69) | PDGFRBKDRCHEK2MAP4K4CHEK1 | |
| SCHEMBL29124905 | 0.79 | IKBKE (0.58) | PDGFRBKDRCHEK2MAP4K4CHEK1 | |
| SCHEMBL16690867 | 0.78 | VRK1 (0.43) | PDGFRBKDRCHEK2MAP4K4FYN | |
| SCHEMBL1328382 | 0.77 | KDM4E (0.51) | PDGFRBKDRIKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478145-B | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116478145-A | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-07-25 | — | — | CN | disclosed |