Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25380258 | 1.00 | GRIN1 (0.43) | GRIN1GRIN2BMAPTPOLBCYP11B1 | |
| SCHEMBL30510003 | 0.92 | CYP11B1 (0.48) | MAPTPOLBCYP11B1CYP11B2KDM4E | |
| SCHEMBL25378904 | 0.92 | CYP11B1 (0.48) | MAPTPOLBCYP11B1CYP11B2KDM4E | |
| SCHEMBL26192887 | 0.90 | POLB (0.46) | GRIN1GRIN2BMAPTPOLBCYP11B1 | |
| SCHEMBL26192893 | 0.90 | MAPT (0.42) | GRIN1GRIN2BMAPTPOLBCYP11B1 | |
| SCHEMBL30510183 | 0.85 | POLB (0.41) | MAPTPOLBCYP11B1CYP11B2KDM4E | |
| SCHEMBL25379857 | 0.85 | POLB (0.41) | MAPTPOLBCYP11B1CYP11B2KDM4E | |
| SCHEMBL25257139 | 0.84 | HTT (0.44) | MAPTPOLBCYP11B1CYP11B2KDM4E | |
| SCHEMBL30509940 | 0.84 | HTT (0.44) | MAPTPOLBCYP11B1CYP11B2KDM4E | |
| SCHEMBL25377104 | 0.83 | GRIN2B (0.44) | GRIN1GRIN2BMAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452253-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | The Katholieke Universiteit Leuven (BE) | 2024-10-30 | — | — | EP | disclosed |
| WO-2023122780-A9 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-11-30 | — | — | WO | disclosed |
| WO-2023122780-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-06-29 | — | — | WO | disclosed |