Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.68 |
| ▸ | JAK1 | P23458 | 12/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23522356 | 1.00 | JAK2 (0.68) | JAK2JAK1 | |
| SCHEMBL30018533 | 0.89 | JAK2 (0.65) | JAK2JAK1 | |
| SCHEMBL20399935 | 0.89 | JAK2 (0.65) | JAK2JAK1 | |
| SCHEMBL30017095 | 0.87 | JAK2 (0.66) | JAK2JAK1 | |
| SCHEMBL20400007 | 0.87 | JAK2 (0.66) | JAK2JAK1 | |
| SCHEMBL30092437 | 0.87 | JAK2 (0.65) | JAK2JAK1 | |
| SCHEMBL23130600 | 0.87 | JAK2 (0.65) | JAK2JAK1 | |
| SCHEMBL23130582 | 0.81 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL30019029 | 0.81 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL20411260 | 0.81 | JAK2 (1.00) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219470-A1 | JAK1 SELECTIVE INHIBITORS | Astrazeneca AB (SE) | 2023-08-02 | — | — | EP | disclosed |