Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.78 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372138 | 0.88 | EGFR (1.00) | EGFRPDGFRBPDGFRAFGFR4PIK3CD | |
| SCHEMBL31728944 | 0.87 | EGFR (0.78) | EGFRPDGFRBPDGFRAHPGDS | |
| Hydrochloric Acid SCHEMBL28032872 | 0.86 | EGFR (0.96) | EGFRPDGFRBPDGFRAFGFR4PIK3CD | |
| Biphenyl SCHEMBL28023494 | 0.78 | EGFR (0.79) | EGFRPDGFRBPDGFRAFGFR4PIK3CD | |
| SCHEMBL28243443 | 0.78 | EGFR (0.70) | EGFRFGFR4PIK3CDPIK3CAALDH1A1 | |
| SCHEMBL28158032 | 0.75 | EGFR (0.76) | EGFRPDGFRBPDGFRAFGFR4PIK3CD | |
| SCHEMBL27399910 | 0.75 | EGFR (0.65) | EGFRPDGFRBPDGFRAFGFR4PIK3CD | |
| SCHEMBL535665 | 0.74 | EGFR (0.64) | EGFRFGFR4PIK3CDPIK3CAALDH1A1 | |
| SCHEMBL668493 | 0.74 | EGFR (1.00) | EGFRPDGFRBPDGFRAALDH1A1HPGDS | |
| SCHEMBL29517021 | 0.74 | EGFR (1.00) | EGFRPDGFRBPDGFRAALDH1A1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293533-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2023-09-21 | — | — | US | disclosed |
| US-11723908-B2 | Quinazoline derivatives as antitumor agents | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2023-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11723908-B2 | Quinazoline derivatives as antitumor agents | ABL1, TP53, JAK1 | EGFR 117/4885PDGFRB 334/4885PDGFRA 250/4885 |
| US-20230293533-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ABL1, TP53, JAK1 | EGFR 117/4885PDGFRB 334/4885PDGFRA 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.