Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.64 |
| ▸ | ACLY | P53396 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PYGL | P06737 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9997183 | 1.00 | HSD17B10 (1.00) | HSD17B10HPGDMAPK1PFKFB3ACLY | |
| SCHEMBL9997155 | 0.88 | HSD17B10 (0.79) | HSD17B10HPGDMAPK1PFKFB3ACLY | |
| SCHEMBL9997277 | 0.86 | HSD17B10 (0.76) | HSD17B10HPGDMAPK1PFKFB3ACLY | |
| SCHEMBL15055714 | 0.86 | HSD17B10 (0.76) | HSD17B10HPGDMAPK1PFKFB3ACLY | |
| SCHEMBL9997275 | 0.84 | HSD17B10 (0.73) | HSD17B10HPGDMAPK1PFKFB3ACLY | |
| SCHEMBL9996952 | 0.84 | HPGD (0.72) | HSD17B10HPGDMAPK1PFKFB3ACLY | |
| SCHEMBL9997160 | 0.82 | HSD17B10 (0.70) | HSD17B10HPGDPFKFB3ALDH1A1MEN1 | |
| SCHEMBL9997013 | 0.81 | HSD17B10 (0.67) | HSD17B10HPGDPFKFB3ACLYALDH1A1 | |
| SCHEMBL9997287 | 0.80 | HSD17B10 (0.67) | HSD17B10HPGDPFKFB3ACLYALDH1A1 | |
| SCHEMBL9997206 | 0.80 | HSD17B10 (0.66) | HSD17B10HPGDPFKFB3ACLYALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4181911-A1 | THE ROLE OF PMCIC IN THE TUMOR MICROENVIRONMENT | Universitätsklinikum Regensburg (DE) | 2023-05-24 | — | — | EP | disclosed |