SCHEMBL30518554

SCHEMBL30518554

Cc1ccc(-c2ccc(CNc3nc(-c4cccnc4)nc4c3ncn4C(C)C)nc2)cn1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 16/20 0.53
CCNE1 P24864 13/20 0.53
CCNE2 O96020 3/20 0.53
CCNA2 P20248 3/20 0.53
CCNA1 P78396 3/20 0.53
CDK9 P50750 6/20 0.49
MEN1 O00255 1/20 0.48
ALDH1A1 P00352 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
KMT2A Q03164 1/20 0.48
HSD17B10 Q99714 1/20 0.48
CDK1 P06493 12/20 0.47
CDK4 P11802 11/20 0.47
CDK7 P50613 11/20 0.47
CCNH P51946 10/20 0.47
MAPK1 P28482 10/20 0.47
CCNB1 P14635 10/20 0.47
CCND1 P24385 9/20 0.47
CCNT1 O60563 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25308603 1.00 CDK2 (0.53) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL25309378 0.96 CDK2 (0.56) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL30518560 0.96 CDK2 (0.56) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL30518558 0.93 CDK2 (0.55) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL25259519 0.93 CDK2 (0.55) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL25309012 0.92 CDK2 (0.50) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL30518540 0.92 CDK2 (0.50) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL25306155 0.89 CDK2 (0.51) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL30518549 0.89 CDK2 (0.51) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL25308606 0.86 CCNK (0.61) CDK2CCNE1CCNE2CCNA2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023140640-A1 HETEROARYL DERIVATIVE AND USES THEREOF 한양대학교 산학협력단 2023-07-27 WO claimed