Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 13/20 | 0.51 |
| ▸ | MTOR | P42345 | 4/20 | 0.48 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.48 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2566425 | 0.99 | PIK3CA (0.50) | PIK3CAPIK3R1MTORRICTORRPTOR | |
| SCHEMBL2565055 | 0.95 | PIK3CA (0.51) | PIK3CAPIK3R1MTORRICTORRPTOR | |
| Hydrochloric Acid SCHEMBL2565069 | 0.94 | PIK3CA (0.50) | PIK3CAPIK3R1MTORRICTORRPTOR | |
| SCHEMBL2574180 | 0.82 | PIK3CA (0.41) | PIK3CAPIK3R1MTORRICTORRPTOR | |
| SCHEMBL2571185 | 0.82 | PIK3CA (0.53) | PIK3CAPIK3R1MTORRICTORRPTOR | |
| SCHEMBL16667531 | 0.81 | PIK3CA (0.42) | PIK3CAPIK3R1MTORRICTORRPTOR | |
| SCHEMBL1360066 | 0.81 | PIK3R1 (0.51) | PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL16667502 | 0.81 | PIK3CA (0.42) | PIK3CAPIK3R1MTORRICTORRPTOR | |
| Hydrochloric Acid SCHEMBL2568691 | 0.81 | PIK3CA (0.53) | PIK3CAPIK3R1MTORRICTORRPTOR | |
| SCHEMBL1359842 | 0.80 | PIK3CA (0.47) | PIK3CAPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056320-A2 | PI3K/MTOR KINASE INHIBITORS | TYROGENEX, INC. (US) | 2010-05-20 | — | — | WO | disclosed |