Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 15/20 | 0.53 |
| ▸ | SMARCA2 | P51531 | 14/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 14/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25347846 | 1.00 | PBRM1 (0.53) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL30520235 | 0.87 | SMARCA2 (0.50) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL25347731 | 0.87 | SMARCA2 (0.50) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL27024902 | 0.85 | SCN9A (0.41) | ITGB3ITGA2BSCN9APDE4B | |
| Hydrochloric Acid SCHEMBL30520261 | 0.84 | PBRM1 (0.55) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| Hydrochloric Acid SCHEMBL25348521 | 0.84 | PBRM1 (0.55) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| Hydrochloric Acid SCHEMBL25269565 | 0.84 | SCN9A (0.41) | ITGB3ITGA2BSCN9APDE4B | |
| SCHEMBL30520294 | 0.83 | SMARCA2 (0.58) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL25349652 | 0.83 | SMARCA2 (0.58) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL23772810 | 0.79 | PBRM1 (0.49) | PBRM1SMARCA2SMARCA4NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4476225-A1 | 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | Aurigene Oncology Limited (IN) | 2024-12-18 | — | — | EP | disclosed |
| CN-118871440-A | 3-Substituted pyridazine compounds as SMARCA2 and/or SMARCA4 degrading agents | 奥瑞基尼肿瘤有限公司 | 2024-10-29 | — | — | CN | disclosed |