Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | GPR6 | P46095 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3062116 | 0.92 | PDE10A (0.49) | PDE10APDE3BPDE3AGPR6LMNA | |
| SCHEMBL3056015 | 0.89 | PDE10A (0.56) | PDE10ACHRM4PDE3BPDE3ALMNA | |
| SCHEMBL3057181 | 0.89 | PDE10A (0.47) | PDE10ACHRM4PDE3BPDE3ASCD | |
| SCHEMBL3062929 | 0.86 | CHRM4 (0.43) | PDE10ACHRM4PDE3BPDE3ASCD | |
| SCHEMBL3051976 | 0.86 | PDE10A (0.51) | PDE10APDE3BPDE3ASCDGPR6 | |
| SCHEMBL3051634 | 0.85 | PDE10A (0.54) | PDE10APDE3BPDE3ASCDLMNA | |
| SCHEMBL3059796 | 0.85 | PDE10A (0.49) | PDE10APDE3BPDE3AGPR6LMNA | |
| SCHEMBL3049692 | 0.83 | PDE10A (0.48) | PDE10ACHRM4PDE3BPDE3AGPR6 | |
| SCHEMBL3056473 | 0.83 | PDE10A (0.46) | PDE10A | |
| SCHEMBL3057869 | 0.83 | PDE10A (0.57) | PDE10APDE3BPDE3ASCDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222353-A1 | AMINOPHTHALAZINE DERIVATIVE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-09-02 | — | — | US | claimed |
| EP-1981868-A2 | AMINOPHTHALAZINE DERIVATIVE COMPOUNDS | Pfizer Products Inc. (US) | 2008-10-22 | — | — | EP | claimed |
| WO-2007085954-A2 | AMINOPHTHALAZINE DERIVATIVE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-08-02 | — | — | WO | claimed |
| US-20100222353-A1 | AMINOPHTHALAZINE DERIVATIVE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-09-02 | — | — | US | disclosed |
| EP-1981868-A2 | AMINOPHTHALAZINE DERIVATIVE COMPOUNDS | Pfizer Products Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085954-A2 | AMINOPHTHALAZINE DERIVATIVE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222353-A1 | AMINOPHTHALAZINE DERIVATIVE COMPOUNDS | PDE12, PDE5A, PDE2A | PDE10A 6/4885CHRM4 931/4885PDE3B 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.