Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 19/20 | 0.62 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | BLK | P51451 | 1/20 | 0.55 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.55 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.55 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24936162 | 1.00 | KCNH2 (1.00) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 | |
| SCHEMBL29827190 | 1.00 | KCNH2 (1.00) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24936314 | 0.94 | KCNH2 (0.89) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 | |
| SCHEMBL29827412 | 0.91 | KCNH2 (0.83) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 | |
| SCHEMBL30522706 | 0.91 | KCNH2 (0.83) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24945667 | 0.91 | KCNH2 (0.83) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24936265 | 0.90 | KCNH2 (0.81) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24935537 | 0.90 | KCNH2 (0.81) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 | |
| SCHEMBL1972711 | 0.89 | KCNH2 (0.81) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 | |
| SCHEMBL30093122 | 0.89 | KCNH2 (0.81) | KCNH2CHEK1NUAK1CHEK2RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119403571-A | Therapeutic agent for cancer having therapeutic resistance to immune checkpoint inhibitor | 住友制药株式会社 | 2025-02-07 | — | — | CN | disclosed |
| CN-116546974-A | 5-heteroaryl-1H-pyrazol-3-amine derivatives | 住友制药株式会社 | 2023-08-04 | — | — | CN | disclosed |