SCHEMBL30523398

SCHEMBL30523398

Nc1nc(NCc2cccc(Cl)c2)c2[nH]cnc2n1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TMIGD3 P0DMS9 2/20 0.78
HTR2B P41595 2/20 0.78
HTR2C P28335 1/20 0.78
CDK1 P06493 1/20 0.73
CDC7 O00311 1/20 0.69
DBF4 Q9UBU7 1/20 0.69
BRAF P15056 6/20 0.65
PIN1 Q13526 1/20 0.64
ADORA3 P0DMS8 2/20 0.61
ADRA2B P18089 1/20 0.61
ADORA1 P30542 1/20 0.61
NUDT1 P36639 1/20 0.60
APP P05067 1/20 0.57
PDE4A P27815 1/20 0.53
PDE4B Q07343 1/20 0.53
PDE4C Q08493 1/20 0.53
PDE4D Q08499 1/20 0.53
HDAC1 Q13547 1/20 0.53
EGFR P00533 1/20 0.50
AURKA O14965 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16147072 1.00 TMIGD3 (0.78) TMIGD3HTR2BHTR2CCDK1CDC7
SCHEMBL30523389 0.86 TMIGD3 (0.78) TMIGD3HTR2BHTR2CCDK1CDC7
SCHEMBL30523361 0.86 CDK1 (0.73) TMIGD3HTR2BHTR2CCDK1CDC7
SCHEMBL16146765 0.86 CDK1 (0.73) TMIGD3HTR2BHTR2CCDK1CDC7
SCHEMBL30523376 0.86 TMIGD3 (0.78) TMIGD3HTR2BHTR2CCDK1CDC7
SCHEMBL16146134 0.86 TMIGD3 (0.78) TMIGD3HTR2BHTR2CCDK1CDC7
SCHEMBL16146231 0.86 TMIGD3 (0.78) TMIGD3HTR2BHTR2CCDK1CDC7
SCHEMBL16146972 0.86 CDK1 (0.73) TMIGD3HTR2BHTR2CCDK1CDC7
SCHEMBL27587370 0.86 CDK1 (0.73) TMIGD3HTR2BHTR2CCDK1CDC7
SCHEMBL16146460 0.86 CDK1 (0.73) TMIGD3HTR2BHTR2CCDK1CDC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116492347-A Compound for activating AMPK and application thereof 华安医学股份有限公司 2023-07-28 CN disclosed