Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 3/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 3/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30955006 | 0.88 | NR1H2 (0.38) | NR1H2STSEPHX2MMP1MMP3 | |
| SCHEMBL31287199 | 0.83 | EPHX1 (0.34) | NR1H2STSEPHX2RORCEPHX1 | |
| SCHEMBL25387176 | 0.79 | — | — | |
| SCHEMBL31722227 | 0.79 | PIK3CD (0.39) | NR1H2STSGPR119EPHX2MMP1 | |
| SCHEMBL38650921 | 0.79 | PIK3CD (0.39) | NR1H2STSGPR119EPHX2MMP1 | |
| SCHEMBL30954989 | 0.79 | PIK3CD (0.39) | NR1H2STSGPR119EPHX2MMP1 | |
| SCHEMBL31209707 | 0.77 | EPHX1 (0.39) | NR1H2EPHX2RORCEPHX1USP2 | |
| SCHEMBL31209512 | 0.77 | EPHX1 (0.39) | NR1H2EPHX2RORCEPHX1USP2 | |
| SCHEMBL17107692 | 0.74 | EPHX1 (0.39) | NR1H2EPHX2RORCDDB1CRBN | |
| SCHEMBL31209428 | 0.73 | EPHX2 (0.38) | NR1H2EPHX2RORCDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583502-A | Bicyclic-heterocyclic derivatives and their use as orexin-2 receptor agonists | 欧瑞夏治疗有限公司 | 2023-08-11 | — | — | CN | disclosed |