Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLQ | O75417 | 11/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CTSA | P10619 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25307178 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2POLQABL1ALDH1A1GAA | |
| SCHEMBL30526555 | 0.90 | POLQ (0.46) | SMN1; SMN2POLQABL1CTSA | |
| SCHEMBL30526837 | 0.88 | POLQ (0.53) | POLQABL1 | |
| SCHEMBL30526583 | 0.84 | POLQ (0.51) | POLQ | |
| SCHEMBL29212784 | 0.84 | POLQ (0.48) | SMN1; SMN2POLQALDH1A1GAA | |
| SCHEMBL30282812 | 0.84 | POLQ (0.48) | SMN1; SMN2POLQALDH1A1GAA | |
| SCHEMBL30640246 | 0.83 | POLQ (0.53) | SMN1; SMN2POLQALDH1A1GAA | |
| SCHEMBL29694834 | 0.83 | POLQ (0.53) | SMN1; SMN2POLQALDH1A1GAA | |
| SCHEMBL24501141 | 0.83 | POLQ (0.53) | SMN1; SMN2POLQALDH1A1GAA | |
| SCHEMBL24770154 | 0.82 | POLQ (0.65) | POLQGAACTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026766-A1 | Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors | BEIGENE, LTD. (KY) | 2025-01-23 | — | — | US | disclosed |
| EP-4463456-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BeiGene, Ltd. (KY) | 2024-11-20 | — | — | EP | disclosed |
| WO-2023134708-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BEIGENE , LTD. (KY) | 2023-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026766-A1 | Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors | POLQ, POLK, POLI | SMN1; SMN2 4018/4885POLQ 1/4885ABL1 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.